刘

研究员

催化基础国家重点实验室

电话:+86-411-84379302    

传真:+86-411-84694447    

电邮:yanliu503@dicp.ac.cn

       

1998年于兰州大学获学士学位,2006年于中国科学院上海有机化学研究所获博士学位,并于同年7月进入美国Brandeis大学Li Deng小组做博士后研究,发表J. Am. Chem. Soc. 5 篇。2010年作为大连化学物理研究所“百人计划”引进人才加入503组,2013年晋升为研究员。回国后在国际刊物知名刊物上已发表多篇论文。

 

主要研究方向:
1.手性乳液催化剂的设计、合成及应用。
 在水油两相体系中,利用油水双亲性催化剂分子在界面组装形成纳米到微米级的分子聚集体作为“微反应器”催化手性反应,实现调变反应性能、产物分离和催化剂的回收使用。

2. 手性材料的合成、表征及应用。
将有机合成、材料化学及手性催化结合起来,合成具有手性催化功能单元的材料,在分子尺度上对手性材料进行调控,调变其在催化反应中的催化性能并实现催化剂的回收使用。

3. 新型手性有机小分子催化剂的设计、合成及应用。
从生物催化,特别是酶催化的催化机理入手,设计、合成结构新颖的手性有机小分子催化剂,完成全新的和尚未解决的不对称催化反应。

4. 光催化的有机合成反应研究。

代表性文章 (*为通讯联系人) 

2011年之后

1. Formal Asymmetric Catalytic Thiolation for the Synthesis of Benzyl Thiols with Bifunctional Catalyst on the Water-oil Interface.  
Wengang Guo, Bo Wu, Xin Zhou, Ping Chen, Xu Wang, Yong-Gui Zhou, Yan Liu,* Can Li*  
Angew. Chem. Int. Ed., 2015, 54, DOI: 10.1002/anie.201409894

2. Well-defined BiOCl Colloidal Ultrathin Nanosheets with High Performance in Photocatalytic Aerobic Oxidation of Secondary Amines  
 Yihui Wu, Bo Yuan,  Mingrun Li, Wen-Hua Zhang,* Yan Liu,* Can Li *
Chemical Science., 2015, 6, 1873.

3. Conjugated microporous polymers with chiral BINAP ligand built in as efficient catalyst on asymmetric hydrogenation.  
Xu Wang, Sheng-mei Lu, Jun Li, Yan Liu*, Can Li*
Catal. Sci. Technol, 2015, 5, DOI: 10.1039/c5cy00038f.

4. Photocatalytic Aerobic oxidation of amine to imine on BiVO4 with visible light.
Bo Yuan, Ruifeng Chong, Bao Zhang, Jun Li, Yan Liu,* Can Li*
Chem. Commun. 2014, 50, 15593-15596.

5. Facile synthesis of Chiral Spirooxindole-based Isotetronic Acids and 5-1H-pyrrol-2-ones via Cascade Reactions with Bifunctional Organocatalysts  
Wengang Guo, Xu Wang, Boyu Zhang, Shuai Shen, Xin Zhou, Peng Wang, Yan Liu*, Can Li*.
Chem. Eur. J. 2014, 20, 8545 – 8550.

6. The Synthesis of Chiral Isotetronic Acids with Amphiphilic  Imidazole / Pyrrolidine Catalysts Assembled in Oil-in-Water Emulsion Droplets 
Boyu Zhang, Zongxuan Jiang, Xin Zhou, Shengmei Lu, Yan Liu*, Can Li*   
Angew. Chem. Int. Ed., 2012, 51, 13159.

7. Acid controlled diastereoselectivity in asymmetric aldol reaction of cycloketones with aldehydes using enamine-based organocatalysts.  
Jinsuo Gao , Shiyang Bai , Qiang Gao , Yan Liu*, Qihua Yang*
Chem. Commun.2011, 47, 6716-6718.

8. Catalytic oxidation of thiophene and its derivatives via dual activation for ultra-deep desulfurization of fuels
 Boyu Zhang, Zongxuan Jiang, Jun Li, Yongna Zhang, Yan Liu*, Can Li*
J. Catal.2012, 287, 5-12.

9. Recyclable chiral diamine–polyoxometalate (POM) acids catalyzed asymmetric direct aldol reaction of aromatic aldehydes with long-chain aliphatic ketones .
    
 Qiang Gao, Sheng-Mei Lu, Yan Liu* and Can Li*
  Tetrahedron Lett., 2011, 52, 3779-3781

10. Construction of anti-1,2-Diols Bearing Chiral Tertiary Alcohol Moiety Using Free Hydroxyacetone as Aldol Donor by Imidazole-based Prolineamide Catalyst
Wengang Guo, Jianwei Wei, Yan Liu*, Can Li*.
Tetrahedron, 2014, 70, 6561 - 6568.

2011年之前(博士和博士后阶段)

1. Catalytic Asymmetric Conjugate Addition of Simple Alkyl Thiols with Bifunctional Catalysts
Yan Liu, Bingfeng Sun, Baomin Wang, Wakem Matthew, Li Deng*
J. Am. Chem. Soc. 2009, 131, 418.

2. Catalytic Enantioselective Peroxidation of a,b-Unsaturated Ketones
Xiaojie Lu, Yan Liu, Bingfeng Sun, Brittany Cindric , Li Deng*
J. Am. Chem. Soc. 2008, 130, 8134.

3. Asymmetric Diels-Alder Reactions of 2-Pyrones with Bifunctional Organic Catalysts
Yi Wang, Hongming Li, Yong-Qiang Wang, Yan Liu, Bruce M. Foxman, Li Deng*
J. Am. Chem. Soc. 2007, 129, 6364.

4. Hydrogen-Bonding makes a difference in the rhodium-catalyzed enantioselective hydrogenation using monodentate phosphoramidites
Yan Liu, Christan A. Sandoval, Yoshiki Yamaguchi, Xue Zhang, Zheng Wang, Koichi Kato, Kuiling Ding*
J. Am. Chem. Soc. 2006, 128, 14212.

5. Modular Monodentate Phosphoramidite Ligands for Rhodium Catalyzed Enantioselective Hydrogenation
Yan Liu, Kuiling Ding*
J. Am. Chem. Soc. 2005, 127, 10488.

6. Structural Study-Guided Development of Versatile Phase-Transfer Catalysts for Asymmetric Conjugate Additions of Cyanide
Brian A. Provencher, Keith J. Bartelson, Yan Liu, Bruce M. Foxman, Li Deng*
Angew. Chem. Int. Ed., 2011, 50, 10565.

7. Highly enantioselective asymmetric Darzens reactions with a phase transfer catalyst
Yan Liu, Brian A. Provencher, Keith J. Bartelson, Li Deng,
Chem. Sci., 2011, 2, 1301.